Niacin Intake May Protect Against Alzheimer's Disease

Medical abstract

High intake of niacin, particularly from food sources, may reduce the risk of Alzheimer's disease and age-related cognitive decline, according to a report in the August issue of the Journal of Neurology, Neurosurgery, and Psychiatry.

Severe niacin deficiency is known to cause dementia. However, the researchers note that it is unclear if more subtle variations in niacin intake influence the risk of neurodegenerative decline.

To investigate, the researchers administered food frequency questionnaires and cognitive tests to several thousand elderly people living in a Chicago community. The study focused on 815 randomly selected subjects who were free from Alzheimer's disease at baseline. After an average of 3.9 years, 131 of the subjects were diagnosed with Alzheimer's disease.

A high level of total niacin intake seemed to protect against both Alzheimer's disease and cognitive decline. The association was stronger for niacin intake from foods than for niacin intake from supplements.

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