Methotrexate Transiently Increases Plasma Homocysteine Levels

Higher doses of methotrexate transiently increase plasma homocysteine levels in patients with rheumatoid arthritis, according to a report in the January 2005 issue of the Annals of the Rheumatic Diseases.

Earlier studies showed substantial rises in homocysteine concentrations during low-dose methotrexate treatment that were mitigated by folate supplementation, the authors explain. Doses higher than 25 mg/week are now being used.

The rise in homocysteine levels appeared smaller in patients using folic acid every day, the researchers note, but the differences were not statistically significant.

"Patients with rheumatoid arthritis who are treated with higher dose methotrexate (25-40 mg), and who receive folate supplementation, do not have raised baseline homocysteine concentrations," the investigators conclude. "However, in most patients, a significant rise in homocysteine concentration occurs in the 48 hours after methotrexate administration."

You Deserve To Feel Better! Give your body the tools it needs to be healthy. This completely natural and powerful antioxidant product delivers amazing results. Improve your health and well-being today. Click and find out how.

-

Try a natural whole food approach.
It's time to take control of your well being through proper nutrition.
Ronnie Allen, ViaViente Independent Distributor.
(352) 419-5171 www.VitalNectars.com

To order by phone, or if you have any questions (352) 419-5171